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Liao, James

One or more keywords matched the following properties of Liao, James

Property	Value
overview	Dr. Liao is the Harold H. Hines Jr. Professor of Medicine and Chief of Cardiology Section at the University of Chicago. He is also the Director of the Physician Scientist Development Program and Principal Investigator of the NIH T32 Cardiovascular Sciences Training Grant. His laboratory has made many important discoveries, which has helped elucidate signaling mechanisms in the vascular wall. Specifically, his laboratory explored molecular pathways which revealed how HMG-CoA reductase inhibitors (or statins) could exert cholesterol-independent or "pleiotropic" effects. This translational work provided a mechanistic basis for the benefit of statin therapy in stroke patients for which he received and was awarded the Cardiovascular Research Prize from the American Heart Association. His laboratory also identified, cloned, and characterized a novel cytochrome P450 epoxygenase, CYP2J2, and its products, epoxyeicosatrienoic acids (EETs), as endothelium-derived hyporpolarizing factors with anti-inflammatory and anti-ischemic properties. In addition, his work also led to the discovery of a novel, rapid, nongenomic effect of steroid hormone receptors. For his research accomplishments, Dr. Liao received the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award from the American Heart Association and the Outstanding Investigator Award from the American Federation for Medical Research. He has served on numerous NIH study sections, advisory committees, and special emphasis panels.

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Value

overview

Dr. Liao is the Harold H. Hines Jr. Professor of Medicine and Chief of Cardiology Section at the University of Chicago. He is also the Director of the Physician Scientist Development Program and Principal Investigator of the NIH T32 Cardiovascular Sciences Training Grant. His laboratory has made many important discoveries, which has helped elucidate signaling mechanisms in the vascular wall. Specifically, his laboratory explored molecular pathways which revealed how HMG-CoA reductase inhibitors (or statins) could exert cholesterol-independent or "pleiotropic" effects. This translational work provided a mechanistic basis for the benefit of statin therapy in stroke patients for which he received and was awarded the Cardiovascular Research Prize from the American Heart Association. His laboratory also identified, cloned, and characterized a novel cytochrome P450 epoxygenase, CYP2J2, and its products, epoxyeicosatrienoic acids (EETs), as endothelium-derived hyporpolarizing factors with anti-inflammatory and anti-ischemic properties. In addition, his work also led to the discovery of a novel, rapid, nongenomic effect of steroid hormone receptors. For his research accomplishments, Dr. Liao received the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award from the American Heart Association and the Outstanding Investigator Award from the American Federation for Medical Research. He has served on numerous NIH study sections, advisory committees, and special emphasis panels.

One or more keywords matched the following items that are connected to Liao, James

Item Type	Name
Concept	Age Factors
Concept	DNA-Binding Proteins
Concept	Insulin
Concept	Immunologic Factors
Concept	Atrial Natriuretic Factor
Concept	Virulence Factors, Bordetella
Concept	Platelet-Derived Growth Factor
Concept	Nerve Growth Factors
Concept	Protein Binding
Concept	Transcription Factors
Concept	Risk Factors
Concept	Insulin Resistance
Concept	Endothelial Growth Factors
Concept	Time Factors
Concept	Tumor Necrosis Factor-alpha
Concept	Macrophage Colony-Stimulating Factor
Concept	Peptide Elongation Factor 1
Concept	Guanine Nucleotide Exchange Factors
Concept	rho GTP-Binding Proteins
Concept	rhoB GTP-Binding Protein
Concept	rac1 GTP-Binding Protein
Concept	Transforming Growth Factor beta
Concept	Sp1 Transcription Factor
Concept	GTP-Binding Protein alpha Subunits, Gs
Concept	Interferon-Stimulated Gene Factor 3
Concept	GTP-Binding Protein alpha Subunits, Gi-Go
Concept	Vascular Endothelial Growth Factor Receptor-2
Concept	Vascular Endothelial Growth Factors
Concept	Sterol Regulatory Element Binding Protein 2
Concept	Transcription Factor AP-1
Concept	rhoA GTP-Binding Protein
Concept	rac GTP-Binding Proteins
Concept	Early Growth Response Protein 1
Concept	Socioeconomic Factors
Concept	Interferon Regulatory Factors
Concept	GATA4 Transcription Factor
Concept	Sex Factors
Concept	Transcription Factor RelA
Concept	GTP-Binding Proteins
Concept	Myeloid Differentiation Factor 88
Concept	cdc42 GTP-Binding Protein
Concept	Monomeric GTP-Binding Proteins
Concept	Basic Helix-Loop-Helix Transcription Factors
Concept	Vascular Endothelial Growth Factor A
Concept	GTP-Binding Protein alpha Subunits, Gq-G11
Concept	Carrier Proteins
Concept	Vascular Endothelial Growth Factor Receptor-1
Concept	GATA2 Transcription Factor
Academic Article	Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.
Academic Article	Increased Rho kinase activity in a Taiwanese population with metabolic syndrome.
Academic Article	Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.
Academic Article	Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2.
Academic Article	Essential role of endothelial Notch1 in angiogenesis.
Academic Article	Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
Academic Article	Pleiotropic effects of statins. - Basic research and clinical perspectives -.
Academic Article	Smooth muscle Notch1 mediates neointimal formation after vascular injury.
Academic Article	ROCK inhibition prevents fetal serum-induced alteration in structure and function of organ-cultured mesenteric artery.
Academic Article	Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina.
Academic Article	Increased Rho kinase activity in congestive heart failure.
Academic Article	Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.
Academic Article	Statins inhibit Rho kinase activity in patients with atherosclerosis.
Academic Article	Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen.
Academic Article	Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice.
Academic Article	Rho-associated kinase activity, endothelial function, and cardiovascular risk factors.
Academic Article	Induction of endothelial-leukocyte interaction by interferon-gamma requires coactivation of nuclear factor-kappaB.
Academic Article	A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms.
Academic Article	Isoprenoid metabolism and the pleiotropic effects of statins.
Academic Article	Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation.
Academic Article	Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF.
Academic Article	Mitohormesis: another pleiotropic effect of statins?
Academic Article	A mouse model of diet-induced obesity and insulin resistance.
Academic Article	Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension.
Academic Article	ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.
Academic Article	FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1.
Academic Article	Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
Academic Article	Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription.
Academic Article	The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor.
Academic Article	Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channel.
Academic Article	Rac1 is a critical mediator of endothelium-derived neurotrophic activity.
Academic Article	Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells.
Academic Article	Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.
Academic Article	VEGF increases retinal vascular ICAM-1 expression in vivo.
Academic Article	Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.
Academic Article	3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1).
Academic Article	Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinase.
Academic Article	Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
Academic Article	Cross-coupling between the oestrogen receptor and phosphoinositide 3-kinase.
Academic Article	Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.
Academic Article	Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment.
Academic Article	Rho GTPases, statins, and nitric oxide.
Academic Article	Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen.
Academic Article	Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis.
Academic Article	Neuroprotection mediated by changes in the endothelial actin cytoskeleton.
Academic Article	Clinical implications for statin pleiotropy.
Academic Article	ROCKs as immunomodulators of stroke.
Academic Article	Pleiotropic effects of statin therapy: molecular mechanisms and clinical results.
Academic Article	A combination of increased Rho kinase activity and N-terminal pro-B-type natriuretic peptide predicts worse cardiovascular outcome in patients with acute coronary syndrome.
Academic Article	Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2.
Academic Article	Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha.
Academic Article	Requirement of Rac1 in the development of cardiac hypertrophy.
Academic Article	Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.
Academic Article	Modulation of bradykinin receptor ligand binding affinity and its coupled G-proteins by nitric oxide.
Academic Article	Simvastatin decreases IL-6 and IL-8 production in epithelial cells.
Academic Article	Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1.
Academic Article	Statins and myocardial hypertrophy.
Academic Article	Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.
Academic Article	Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants.
Academic Article	Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase.
Academic Article	Novel aspects of the roles of Rac1 GTPase in the cardiovascular system.
Academic Article	RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis.
Academic Article	Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase.
Academic Article	Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1.
Academic Article	Regulation of G-protein alpha i2 subunit expression by oxidized low-density lipoprotein.
Academic Article	FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.
Academic Article	NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy.
Academic Article	Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection.
Academic Article	Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.
Academic Article	Fine-tuning the angiogenic response to vascular endothelial growth factor.
Academic Article	Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids.
Academic Article	Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase.
Academic Article	Rho-associated kinase activity is a predictor of cardiovascular outcomes.
Academic Article	MnTBAP stimulates angiogenic functions in endothelial cells through mitofusin-1.
Academic Article	Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome.
Academic Article	ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice.
Academic Article	Statin therapy is associated with improved patency of autogenous infrainguinal bypass grafts.
Academic Article	Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study.
Academic Article	Critical role of endothelial Notch1 signaling in postnatal angiogenesis.
Academic Article	Elevated homocysteine and C-reactive protein levels independently predict worsening prognosis after stroke in Chinese patients.
Academic Article	11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.
Academic Article	MnTBAP increases BMPR-II expression in endothelial cells and attenuates vascular inflammation.
Academic Article	Activation of guanine nucleotide-binding proteins and induction of endothelial tissue-type plasminogen activator gene transcription by alcohol.
Academic Article	Targeting Rho in cardiovascular disease.
Academic Article	Specific receptor-guanine nucleotide binding protein interaction mediates the release of endothelium-derived relaxing factor.
Academic Article	Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1.
Academic Article	Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms.
Academic Article	Cardiology Consultation in the Emergency Department Reduces Re-hospitalizations for Low-Socioeconomic Patients with Acute Decompensated Heart Failure.
Academic Article	Tumor necrosis factor-a levels and non-surgical bleeding in continuous-flow left ventricular assist devices.
Academic Article	Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase.
Academic Article	The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia.
Academic Article	Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.
Academic Article	Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4.
Academic Article	Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.
Academic Article	Association of Rising Violent Crime With Blood Pressure and Cardiovascular Risk: Longitudinal Evidence From Chicago, 2014-2016.
Academic Article	Community Health Workers Reduce Rehospitalizations and Emergency Department Visits for Low-Socioeconomic Urban Patients With Heart Failure.
Academic Article	Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.
Academic Article	SALAD-BAAR: A numerical risk score for hospital admission or emergency department presentation in ambulatory patients with cardiovascular disease.
Academic Article	Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury.
Grant	GTP-BINDING PROTEINS AND MEDIATING EDRF RELEASE
Grant	Cellular Determinants of Adipocyte Phenotype and Function
Grant	Novel Signaling Pathways in Ischemic Stroke
Grant	Endothelial Akt in Vascular Injury
Grant	ROCK and Obesity
Grant	Lipoproteins Effect on G Protein Function
Grant	Mechanisms Underlying Vascular Aging
Academic Article	Understanding the molecular mechanisms of statin pleiotropic effects.

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